Stay near the banks of the Ohio and Mississippi rivers at the Quality Inn hotel in Cairo, Illinois. Our location off Interstate 57 provides convenient access to Fort Defiance State Park, Wickliffe Mounds State Park, Magnolia Manor, Birds Blue Hole and Cypress Creek National Wildlife Refuge.
Our proximity to the neighboring states of Missouri and Kentucky provide even more to see and do. Explore Cairo's historic district, where you'll find the Old Custom House, a former post office and courthouse that now serves as a museum. Several shops and restaurants are also close by.